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首页> 外文OA文献 >EXPERIMENTAL INDUCTION OF ATHERO-ARTERIOSCLEROSIS BY THE SYNERGY OF ALLERGIC INJURY TO ARTERIES AND LIPID-RICH DIET : I. EFFECT OF REPEATED INJECTIONS OF HORSE SERUM IN RABBITS FED A DIETARY CHOLESTEROL SUPPLEMENT
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EXPERIMENTAL INDUCTION OF ATHERO-ARTERIOSCLEROSIS BY THE SYNERGY OF ALLERGIC INJURY TO ARTERIES AND LIPID-RICH DIET : I. EFFECT OF REPEATED INJECTIONS OF HORSE SERUM IN RABBITS FED A DIETARY CHOLESTEROL SUPPLEMENT

机译：对动脉和富含脂质的饮食的过敏性增效协同作用对实验性动脉粥样硬化的诱导：I.反复注射高脂血清对饮食中补充胆固醇的兔子的影响

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In rabbits that received a dietary supplement of cholesterol, 0.5% by weight, and concommittant injections of horse serum (group III) over a period of 80 days, coronary arterial lesions developed that in the main were different in quality and distribution from those in rabbits that received the cholesterol supplement alone (group I), and of different quality from but in distribution similar to those in rabbits that received horse serum alone (group II). Fatty lesions developed in small, rarely in medium, but never in large arteries of rabbits in group I, and these changes do not resemble coronary athero-arteriosclerosis in man. Proliferative lesions without fatty change developed in large, medium, and small arteries of rabbits in group II, and some of these closely resemble human coronary arteriosclerosis without fatty change. The changes that developed in large, medium, and small arteries of rabbits in group III were in very large majority fatty-proliferative lesions. Some of these closely resemble the changes that in some cases constitute coronary athero-arteriosclerosis in man. Nuclei with caterpillarlike chromatin pattern in longitudinal section and owl eye appearance in transverse section were observed to occur in many of the proliferating cells in thickened arterial intima in hearts of rabbits in groups II and III and in some of the lipid rich "foam" cells in arterial intima and subjacent media in hearts of rabbits in group III. Such nuclei have been observed to occur in some reacting smooth muscle cells and normal immature and reacting mature striated muscle cells of the heart. These observations indicate that at least many of the cells, including "foam" cells, in thickened intima in the experimentally induced and in naturally occurring coronary athero-arteriosclerosis are smooth muscle cells that evolved in proliferative reaction to arterial injury. Fatty change developed in aortas of the rabbits in groups I and III, and was significantly greater in group III. Results of this investigation support the hypothesis that the synergy of allergic injury to arteries and lipid-rich diet can lead to athero-arteriosclerosis.
机译：在饮食中补充胆固醇（按重量计0.5％）并在80天之内同时注射马血清（III组）的兔子中，冠状动脉病变的发展主要与兔子的质量和分布不同单独接受胆固醇补充剂的动物（I组），其质量与单独接受马血清的兔子的质量不同但分布相似（II组）。第一组兔的脂肪病变在小动脉中发展，很少在中动脉发展，但从未在大动脉中发展，这些变化与人的冠状动脉粥样硬化相似。 II组兔子的大，中，小动脉均发生了无脂肪变化的增生性病变，其中一些与无脂肪变化的人冠状动脉硬化非常相似。在第三组的兔子的大，中，小动脉中发生的变化是绝大多数脂肪增生性病变。其中一些与在某些情况下构成人的冠状动脉粥样硬化的变化非常相似。在第II和第III组兔心脏的增厚的动脉内膜中的许多增殖细胞中和在某些脂质丰富的“泡沫”细胞中均观察到在纵截面上具有毛虫状染色质模式的核，在横截面上具有猫头鹰眼的外观。第三组家兔心脏的动脉内膜和下中膜。已经观察到这种核发生在心脏的一些反应性平滑肌细胞和正常的未成熟反应性和成熟的横纹肌细胞中。这些观察结果表明，在实验诱导的和自然发生的冠状动脉粥样硬化中增厚的内膜中的至少许多细胞，包括“泡沫”细胞，是平滑肌细胞，其在对动脉损伤的增殖反应中进化。脂肪改变在第一和第三组的兔子的主动脉中发生，并且在第三组中显着更大。这项研究的结果支持以下假设：对动脉的过敏性损伤和富含脂质的饮食协同作用可能导致动脉粥样硬化。

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